Stealth-adapted viruses and complex chronic illnesses
Definition: The terms stealth and stealth-adapted refer to actively cell damaging (cytopathic) viruses that lack antigenic components required for effective immune recognition. Infection, therefore, does not provoke an anti-virus inflammatory reaction.
Underlying Principle: Only a relatively few virus components are targeted by the cellular immune system. This limitation is necessary because individual lymphocytes are genetically programmed to recognize single antigenic specificities. Effective lymphocyte: virus infected target cell interaction is based on multiple copies of a relatively few antigenic specificities, rather than a plethora of many antigens. Human cytomegalovirus (CMV) encodes for approximately 150 components. Yet the majority of anti-CMV cytotoxic T cells (CTL) recognize a single viral component and most of the remaining CTL are directed at only 2 additional viral components. CMV lacking these 3 critical components would not be effectively recognized.
Origins: The best characterized stealth-adapted virus arose not from human CMV but from CMV of African green monkeys. The political implication is that these stealth-adapted viruses entered the human population as contaminants of live polio virus vaccines. Stealth-adaptation can conceivably occur with any cytopathic virus, not only herpesviruses of human or animal origins, but also other DNA and RNA viruses.
Cytopathic Effects: Stealth-adapted viruses induce a characteristic foamy vacuolated cytopathic effect, usually accompanied by cell fusion (syncytia) when cultured on human or animal fibroblasts. Similar cellular changes can be observed in tissue biopsies of infected patients and in stealth-adapted virus inoculated animals. The cytopathic effect is remarkable in not being progressive in routine virus culture because of a healing repair process mediated by pigmented material that accumulates in infrequently re-fed cultures.
Alternative Cellular energy pigments (ACE-pigments). Complex intracellular structures can also be seen in tissue biopsies from stealth virus infected patients and animals. Mitochondria show extensive disruption further supporting the argument that these structures are providing an alternative (non-mitochondria) source of cellular energy. They can respond to light and other forms of electromagnetic radiation, can occasionally display ferromagnetic properties and can resonate at certain sound frequencies. They appear capable of converting physical energies into biological energy in much the same way that chlorophyll can convert sunlight into chemical energy. They differ from chlorophyll in being responsive to a much wider range of input energies.
Clinical Associations: Insight into the wide spectrum of diseases caused by stealth-adapted viruses has come from a survey of family illnesses of presumptive infectious origin. It is also provided by what we know regarding disease associations of conventional cell damaging viruses, especially CMV and from the scattered reports of microbes being detected in diseased tissues. : Because different regions of the brain carry out unique functions, this organ more than any other is particularly prone to showing signs of limited localized damage. Not surprisingly, therefore, many stealth-adapted virus infected patients will manifest evidence of brain damage. On a mild level these can include subtle changes in personality, intellect and mood, along with mild but discernable impairments in motor, sensory and/or autonomic nervous system capacity. More severe damage will result in clinical syndromes readily classified by psychiatrists and neurologists. Early lifetime exposure can affect brain development, while old age can unmask previously hidden brain damage. Herpes viruses, and in particular CMV, have been associated with illnesses affecting all of the body’s major organs. A stealth-adapted virus infection should be suspected especially in patients with accompanying neuropsychiatric disorders or a family history of pervasive unexplained complex illnesses. Hepesviruses have also long been suspected as contributing to several forms of human malignancies. A case can be made for a viral component in cancers developing in patients with a clinical or family history of a chronic fatiguing illness.
Transmission. Several accounts have confirmed sexual transmissions. This is, however, by no means the only route of disease transmission. Casual contact, especially within a family, but also in the workplace and at school, can be a source of infection. Stealth-adapted viruses can pass between humans and animals, including domestic pets. Early studies showed that a stealth-adapted virus was resilient to drying suggesting that the environment may be a source of infection. The finding of bacteria-derived sequences within a stealth-adapted virus, together with the isolation of atypical bacteria from the patient’s feces, is a strong indication of virus passage to bacteria.
Therapy: Clinical trials of natural products with ACE-pigment like activities need to be pursued. Their mineral content also has relevance to chelation procedures. I would appreciate hearing from any clinician interested in assisting with these IRB approved trials. Reports of family illnesses of presumptive infectious origin can provide useful insights into disease manifestations as well as offering the chance to directly compare products targeted to a similar stealth-adapted virus. Please communicate either by phone or via e-mail.
Kind regards, W. John Martin, M.D., Ph.D.
Founder, Center for Complex Infectious Diseases
and BioPhysics Institute, Rosemead CA 91770
Phone 626-616-2868 e-mail s3support@mail.com
